Postdoctoral Scientist Positions Mass Spectrometry Research Resource in St. Louis

Postdoctoral Scientist Positions available with Michael Gross, Mass Spectrometry Research Resource, Washington University in St. Louis, Department of Chemistry.

Several opportunities are available immediately for postdoctoral scientists to develop MS-based structural proteomics methods and apply them in protein biophysics and structural proteomics of membrane proteins (MPs), viral proteins, and amyloid-forming proteins.   The research utilizes Fast Photochemical Oxidation of Proteins (FPOP), H/D amide exchange, other protein footprinting, native MS, and ion mobility. 

Amyloid protein research focuses on Ab in Alzheimer’s Disease to develop and apply protein footprinting during aggregation and their interaction with inhibitors culminating in the study of Ab in reprogrammed neurons in collaboration with A Yoo of WU School of Medicine. This is newly funded.

MP research (collaboration with Weikai Li, Dept of Biochemistry and Biophysics at the WU School of Medicine) advances MS-based structural methods in membrane proteins, a frontier in structural biology and novel protein expression and purification. 

Viral protein research emphasizes fundamentals, structure, and interactions with other proteins and antibodies (epitope mapping) for JEV, Zika, Marburg, Ebola, Yellow Fever, Rift Valley Fever, and SARS-CoV-2. This research is a collaboration with G Amarasinghe, D Leung, D Fremont, and M Diamond of WU School of Medicine.

The laboratory is staffed by 2 staff scientists, 5 PhD students, and 2 postdoctoral students.  Instruments include Bruker timsTOF Pro2, 2 Thermo QE orbitraps, a 12 T Bruker FTICR, 3 Bruker MaXis High Performance QToF, one with a Leap Robot for HDX, a Thermo Orbitrap, a Thermo EMR for native MS, and a Waters Synapt G2.

The candidate should have a PhD in Chemistry, Biochemistry, or Biophysics and have experience in mass spectrometry and protein science.  The minimum salary is $58,000 per year. Send application and CV and arrange three electronic reference letters to Michael L Gross (

Michael L. Gross
Professor of Chemistry, Immunology, Medicine
Department of Chemistry, MSC 1134-196-525
Washington University in St. Louis
One Brookings Drive
St. Louis, Mo 63130
Phone:  314-935-4814; Fax:  314-935-7484